The university’s main, 78-acre campus anchors the western end of St. Paul’s historic Summit Avenue.

In 1992 the university opened a permanent campus in downtown Minneapolis, which is home to the Dougherty Fmaily College, and most of the graduate programs in the Opus College of Business, the School of Law, and the College of Education, Leadership and Counseling which encompasses the Professional and Counseling Psychology programs as well as the Education programs.

The Bernardi Residence in Rome, which opened in 2000, is a remodeled residential estate on the banks of the Tiber River. Serving as a home to students on the university’s core semester program and the Center for Catholic Studies' Rome program, the Bernardi Residence is also available for conferences, study tours and housing for faculty, students, and visitors to Rome.