Mandel’s fourth novel, Station Eleven, is a post-apocalyptic novel set in the near future in a world ravaged by the effects of a virus and follows a troupe of Shakespearian actors who travel from town to town around the Great Lakes region. It was nominated for the National Book Award, the PEN/Faulkner Award for Fiction and the Baileys Women's Prize for Fiction, and won the Arthur C. Clarke Award and the Toronto Book Award. A film adaptation of the novel is in development by producer Scott Steindorff.

2016-17 speaker for the English dept/ACTC: Mandel is visiting UST on September, 29th in ASC Woulfe.