Chemistry Seminar: Advances in Ionic Liquid-Based Stationary Phases and Sorbent Materials for Chromatography and Sample Preparation

Dr. Jared Anderson, Iowa State University

Date & Time:

Friday, October 4, 2019
12:15 PM - 1:20 PM

Abstract

Ionic liquids (ILs) can be designed to exhibit unique properties for their use in a number of applications in analytical and bioanalytical chemistry.  This talk will focus on the design and synthesis of ILs, magnetic ionic liquids (MILs), and polymeric ionic liquids (PILs) as well as the use of these materials in a number of applications within multidimensional chromatography and sample preparation. A series of monocationic/dicationic ionic liquid-based and silver-containing stationary phases were evaluated as secondary columns in comprehensive two-dimensional gas chromatography (GC×GC) for the separation of aliphatic hydrocarbons from kerosene as well as the separation of olefins from paraffins. Finally, nucleic acids are biopolymers that constitute important diagnostic molecules for a broad range of applications from clinical testing to forensic analysis. A major challenge faced by DNA and RNA analysis techniques is the selective extraction of particular nucleic acid sequences using rapid and sensitive methodologies. It will be shown that ion-tagged oligonucleotides (ITOs) can be used in conjunction with MILs to efficiently capture DNA sequences from complex samples. The ITOs can be created through thio-lene “click” chemistry and the nature of the ion tag can influence the partitioning of the ITO to the hydrophobic MIL. This novel liquid-phase approach towards sequence-selective DNA capture provides superior extraction efficiencies to conventional magnetic bead technology as well as a platform for using external fields to manipulate the liquid droplets.

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