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Ippoliti, J. Thomas
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Professor Ph. D. Univ. of Wisconsin
jtippoliti@stthomas.edu
Dept. of Chemistry, Mail # OSS 402 Office Location: OWS 462 |
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Other Course Information and LinksEducational Background
Dr. Ippoliti's Schedule
Research (Click here for more information on specific projects)
The students of Dr. Ippoliti’s research group are actively involved in five areas of research. All of these areas utilize organic synthesis to make new molecules. The first area is in the field of diagnostic molecules. Diagnostic molecules are used to detect proteins or other biomolecules that indicate the presence of disease. We have been synthesizing new colorimetric molecules to detect the presence of enzyme metabolites. Using Enzyme Linked ImmunoSorbent Assays (ELISA) we can then utilize our new molecules to detect a variety of important bioactive molecules. The second area is synthesis of novel heterocylic molecules. These molecules can be used to make Zeolites or Metal Organic Frameworks (MOF). Zeolites are inorganic frameworks that can be used for catalysts or separations. MOFs can be used for the storage of fuels in a solid state. The third area is the synthesis of new antibiotics. We have synthesized several new antibiotics recently that are highly active antibacterial agents. We are continuing this work by making new derivatives in this potent class of antibiotics. The fourth area of research is in the area of Green Chemistry. Specifically, we are developing new synthesis of useful chemicals from renewable feedstock or sustainable resources. Most chemicals are derived from oil, a non-renewable feedstock. This field is becoming increasingly important as oil prices rise and reserves are used up. The last area is biomedical in nature. We are synthesizing biocompatible, biodegradable molecules that deliver drugs. These materials can be used to coat implantable medical devices such as stents. All of these areas give the student experience in carrying out reactions, purifying products and structure elucidation using NMR spectroscopy.
Recent Publications and Patents:Ippoliti, J. Thomas; Schewe, Scott R.; Atanasoska, Liliana L.; Warner, Robert W. Nanoparticle precursor, nanoparticle structures and polymer-matrix composite materials. U.S. Patent 7,470,466 (2008) Ebner, David C.; Culhane, Jeffrey C.; Winkelman, Tyler N.; Haustein, Mitchell D.; Ditty, Jayna L.; Ippoliti, J. Thomas. Synthesis of novel oxazolidinone antimicrobial agents. Bioorganic & Medicinal Chemistry 2008, 16(5), 2651-2656 Ippoliti, J. Thomas; Leehy, Katherine A.; Olson, Katherine; Johnson, Allison J. A new ELISA utilizing alcohol oxidase and a latent fluorophore. Abstracts of Papers, 235th ACS National Meeting, New Orleans, LA, United States, April 6-10, 2008 (2008) Ippoliti, J. Thomas. Trapped photochromes and thermochromes and uses for chromogenic detection, including detection of airborne contaminants. U.S. Pat. Appl. Publ. (2005), 22 pp. CODEN: USXXCO US 2005239107 “Zwitterionic superabsorbent polymers” Ippoliti, J. Thomas; Vlaminck, Jay; Hillmyer, Marc A. Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 2005, 46(1), 867-868 “Naphthopyran compounds, photoresponsive compositions and lenses” Hughes, F.J., Qin, X, Ippoliti, J. T. U.S. Patent 6,863,843, 2005 Recent Presentations:
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