Ippoliti, J. Thomas
The students of Dr. Ippoliti's research group are actively involved in five areas of research. All of these areas utilize organic synthesis to make new molecules.
The first area is in the field of diagnostic molecules. Diagnostic molecules are used to detect proteins or other biomolecules that indicate the presence of disease. We have been synthesizing new fluorescent molecules and upconverting nanoparticles to detect the presence of enzymes that are indicative of disease. Using Enzyme Linked ImmunoSorbent Assays (ELISA) and a start-of-the-art handheld detector, we can then utilize our new molecules to detect a variety of important bioactive molecules.
The second area is synthesis of novel heterocyclic molecules. These molecules can be used to make Zeolites or Metal Organic Frameworks (MOF). Zeolites are inorganic frameworks that can be used for catalysts or separations. MOF’s can be used for the storage of fuels in a solid state. The can also be used to capture CO2, a greenhouse gas.
The third area is the synthesis of new antibiotics, antimalarials and molecules active against tuberculosis . We have synthesized several new antibiotics recently based on a molecular topology program that predicted high antibacterial activity. We are also synthesizing novel antimalarial compounds.
The fourth area of research is in the area of thermochromic and photochromic molecules. These molecules change color reversibly with temperature or light, respectively.
The last area is biomedical in nature. We are synthesizing polymeric molecules that are radioopaque. These materials can be used to coat implantable medical devices such as stents so they can be seen using X-radiography.
All of these areas give the student experience in carrying out organic reactions, purifying products and structure elucidation using NMR spectroscopy.
Recent Publications and Patents:
Ippoliti, J. Thomas; Schewe, Scott R.; Atanasoska, Liliana L.; Warner, Robert W. Nanoparticle precursor, nanoparticle structures and polymer-matrix composite materials. U.S. Patent 7,470,466 (2008)
Ebner, David C.; Culhane, Jeffrey C.; Winkelman, Tyler N.; Haustein, Mitchell D.; Ditty, Jayna L.; Ippoliti, J. Thomas. Synthesis of novel oxazolidinone antimicrobial agents. Bioorganic & Medicinal Chemistry 2008, 16(5), 2651-2656
Ippoliti, J. Thomas; Leehy, Katherine A.; Olson, Katherine; Johnson, Allison J. A new ELISA utilizing alcohol oxidase and a latent fluorophore. Abstracts of Papers, 235th ACS National Meeting, New Orleans, LA, United States, April 6-10, 2008 (2008)
Ippoliti, J. Thomas. Trapped photochromes and thermochromes and uses for chromogenic detection, including detection of airborne contaminants. U.S. Pat. Appl. Publ. (2005), 22 pp. CODEN: USXXCO US 2005239107
“Zwitterionic superabsorbent polymers” Ippoliti, J. Thomas; Vlaminck, Jay; Hillmyer, Marc A. Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 2005, 46(1), 867-868